abstract |
The present invention relates to a novel indole carboxamide derivative. In particular, the present invention provides compounds of formula (I): [Wherein R1, R2, R3, U and V are defined below] And a pharmaceutically acceptable salt thereof. The compounds of the invention are inhibitors of IKK2 and are useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). sell. Accordingly, the present invention further relates to pharmaceutical compositions comprising the compounds of the present invention. The invention further relates to a method of inhibiting IKK2 activity and a method of treating disorders associated with the use of a compound of the invention or a pharmaceutical composition comprising the invention. |