| abstract |
The present invention provides 2-amino-5-heteroaryl-5-phenylimidazolone compounds of formula I. The present invention also relates to 2-amino-5-heteroaryl-5-phenylimidazolone compounds of formula I to inhibit β-selectase (BACE) and to treat β-amyloid deposition and neurofibrillary tangles Providing a method for the use of. The invention also relates to the use of amino-5-heteroaryl-imidazolone compounds of formula I for the treatment of β-amyloid deposition and neurofibrillary tangles. The compounds of the invention are particularly useful for treating Alzheimer's disease, cognitive impairment, Down's syndrome, HCHWA-D, cognitive decline, senile dementia, cerebral amyloid angiopathy, degenerative dementia, or other neurodegenerative disorders. |