| abstract |
Disclosed is a mechanism by which a factor VIII inhibitor, which has not been known so far, interferes with the procoagulant action of factor VIII, provides a pharmaceutical composition containing the inhibitor, and provides a pharmaceutical composition containing the inhibitor Provides therapeutic application. A method for determining the presence of a catalytically active anti-factor VIII alloantibody capable of degrading factor VIII in a mammal and a site for cleavage of the factor VIII molecule by the catalytically active anti-factor VIII alloantibody Method. In addition, an inhibitor of factor VIII degradation catalyzed by an anti-factor VIII alloantibody; a pharmaceutical composition comprising the catalytically active anti-factor VIII alloantibody capable of degrading factor VIII resulting from the measurement method; A pharmaceutical composition comprising an inhibitor of factor VIII degradation catalyzed by a factor VIII alloantibody, wherein the pharmaceutical composition comprises an inhibitor of factor VIII degradation catalyzed by the anti-factor VIII alloantibody. [Selection figure] None |