| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fec576c38e34882531ca37d6b922bf42 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B55-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-16 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-06 |
| filingDate |
2009-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76572bc2100ee5c047e61235865eb2ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59e6a3bc070646e22ac3307357d9d3c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f54c83196360dd9a103e7d0b7c4d2666
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd9c94cb75c25d75b0c5734b72b5af4c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff0b8b805b217a873c59c1d47709f388 |
| publicationDate |
2009-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2009286779-A |
| titleOfInvention |
Process for producing α-fluoro-β-amino acids |
| abstract |
The present invention provides an industrial process for producing α-fluoro-β-amino acids. Α-Fluoro-β-amino acids can be produced by reacting β-hydroxy-α-amino acids with sulfuryl fluoride (SO 2 F 2 ) in the presence of an organic base. . By using tertiary amines having 2 or more alkyl groups having 8 to 12 carbon atoms and 3 or more carbon atoms, especially diisopropylethylamine as an organic base, the by-product of quaternary ammonium salt is effective. Can be suppressed. By applying the production method of the present invention, (2R) -3- (dibenzylamino) -2-fluoropropionic acid methyl ester, which is extremely important as a pharmaceutical intermediate, is remarkably industrially produced with high regioselectivity. Can be easily manufactured. [Selection figure] None |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016513100-A |
| priorityDate |
2008-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |