abstract |
Disclosed is a compound for treating chronic or acute pain, which shows affinity for ORL1 receptor and μ, δ and κ receptors. For example, the following representative compounds. (1) 1,2,3,4-tetrahydro-1- [1- (naphth-2-yl-methyl) -4-piperidinyl] -quinolin-2-one (2) 1- [1- (naphth-2) -Yl-methyl) -4-piperidinyl] -2,1,3-benzothiadiazole-2,2-dione (3) 3-butyl-1- [1- [4- (2-propyl) -cyclohexyl] -4 -Piperidinyl] -2,1,3- (3,4-dihydro) -benzothiadiazine-2,2-dione [selection] None |