| abstract |
A fusion protein for use in ligand-dependent transcription is provided. A fusion protein comprising a nucleotide binding domain operably linked to a modified ligand binding domain derived from an intracellular receptor, a fusion protein further comprising a transcription control domain, a polynucleotide encoding the fusion protein, and an expression vector , And transfected cells. The nucleotide binding domain is a zinc finger peptide that binds to an adjacent target nucleotide sequence of about 3 to about 18 nucleotides. The fusion protein is used for gene therapy. [Selection] Figure 10 |