abstract |
Disclosed is a novel compound having affinity for an opioid receptor-like (ORL1) receptor. A compound in which the 4-position carbon of piperidine is bonded to ring atom N of benzoxazole, indole, benzimidazole, or a linear or branched chain compound to ring atom N of benzimidazole, which is an analog of nociceptin Is a substituted compound. Illustrative compound 11 is shown in the following formula. [Selection figure] None |