| abstract |
Disclosed are compounds and methods useful for chemopreventive treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel disease, and multiple sclerosis. 2-Cyano-3,12-dioxooleana-1 is a triterpenoid derivative that has the effect of suppressing transcription or translation of inducible nitric oxide synthase and inducible cyclooxygenase genes, and prevents and treats the above diseases. , 9-diene-28 acid, 2-cyano-3,11-dioxooleana-1,12-diene-28 acid and the like. [Selection figure] None |