http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009242368-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_924252f92d5a166d757f62937b8d26bf |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-382 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 |
| filingDate | 2008-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5596cd89d4350cf9fe9a828a2673e83d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd23ae43cd73942456397864d5183707 |
| publicationDate | 2009-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2009242368-A |
| titleOfInvention | Dorzolamide hydrochloride ophthalmic solution |
| abstract | PROBLEM TO BE SOLVED: To provide dorzolamide hydrochloride ophthalmic solution with reduced eye irritation. SOLUTION: Dorzolamide hydrochloride (chemical name: (−)-(4S, 6S) -4-ethylamino-5,6-dihydro-6-methyl-4H-thieno [2,3-b] thiopyran-2-sulfonamide 7,7 In an ophthalmic solution containing -dioxide monohydrochloride) as an active ingredient, the present inventors have found conditions under which eye irritation is reduced. An ophthalmic solution in which dorzolamide hydrochloride is dissolved in purified water or the like has eye irritation at the time of instillation.Here, in general, when the pH of the ophthalmic solution listed as one factor of eye irritation was confirmed, Although it was 5.5 to 5.9 in the acidic region, as a result of intensive studies by the present inventors, the condition under which eye irritation is reduced when instilled with Dorzolamide hydrochloride ophthalmic solution is pH in the neutral region. In particular, it was found to be 6.5 to 8.5. [Selection figure] None |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110903299-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111084758-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015029923-A1 |
| priorityDate | 2008-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.