| abstract |
A novel antagonist for melanin-concentrating hormone (MCH) is provided. An N-aryl urea derivative formula I, for example trans or cis-1- [2- (1-pyrrolidinyl) ethylamino] -4- (3-cyanophenyl) -4-hydroxycyclohexane. It has melanin-concentrating hormone (MCH) antagonist activity and is applied to obesity, metabolic disorders, eating disorders (eg, bulimia, and diabetes). It also applies to major depression, manic depression, anxiety, schizophrenia and sleep disorders. [Selection figure] None |