| abstract |
A novel process for the synthesis of the antitumor compound temozolomide and intermediates useful in this novel process. The present invention provides a process for the preparation of a compound of formula IA, wherein R is an alkyl group having 1 to 6 carbon atoms, the process comprising reacting a compound of formula II Reacting with a suitable oxidizing / cyclizing agent in the presence of soluble iodide, in an inert medium, under an inert atmosphere, and at a temperature and for a time sufficient to produce a compound of formula IA. [Selection figure] None |