| abstract |
An object of the present invention is to improve the pharmacological activity by replacing the hydroxyl group of a thalidomide metabolite 5′-hydroxythalidomide with a fluorine atom, to inhibit metabolism by an oxidase, and to prevent loss of the pharmacological activity of thalidomide. A novel 5′-fluorothalidomide derivative and a method for producing the derivative are provided. As a 5′-fluorothalidomide derivative, a 2- (5-fluoro-2,6-dioxopiperidin-3-yl) isoindoline-1,3-dione derivative represented by the following formula (1): And a method for producing the derivative. (In the formula, R1, R2, R3, R4 and R5 each independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, etc .; R6 represents a hydrogen atom or a protecting group for an amino group.) [Selection figure] None |