| abstract |
【Task】 A means for controlling angiogenesis, which is difficult to promote angiogenesis by conventional methods, for example, promotes angiogenesis in a specific group of subjects such as the elderly, and more precisely controls angiogenesis at a predetermined site. Provide a means. [Solution] In accordance with the present invention, EC precursors can be used in methods of controlling angiogenesis, i.e., enhancing or inhibiting angiogenesis, in selected patients and in some preferred embodiments targeted to specific sites. For example, EC precursors can be used to enhance angiogenesis or to transport an angiogenesis inhibitor, such as an anti- or parent-angiogenic agent, to a pathological or utilitarian site of angiogenesis, respectively. it can. Furthermore, in another embodiment, EC precursors can induce revascularization of damaged blood vessels and thus are used to reduce restenosis by indirectly inhibiting smooth muscle cell proliferation. Can do. [Selection figure] None |