| abstract |
The present invention provides compounds useful for the treatment or prevention or amelioration of diseases and disorders associated with α2C adrenergic receptors. In many embodiments thereof, the present invention provides novel phenylmorpholine and phenylthiomorpholine compounds, pharmaceutical compositions comprising the compounds, and such compounds or pharmaceutical compositions that serve as α2C adrenergic receptor agonists. The present invention relates to a method for treating, preventing, suppressing or ameliorating one or more diseases associated with an α2C adrenergic receptor agonist. In many embodiments, the present invention provides a novel class of heterocyclic compounds as active or functionally selective α2C adrenergic receptor agonists, or metabolites, stereoisomers thereof (eg, enantiomers or Diastereomers) salts, solvates or polymorphs are provided. [Selection figure] None |