| abstract |
PROBLEM TO BE SOLVED: To provide additional means for identifying and characterizing additional molecules that are members of the TNF family, thereby controlling disease and manipulating the immune system. A DNA sequence encoding a novel tumor necrosis factor-related ligand (TRELL) or a fragment thereof, in one embodiment, a DNA sequence encoding TRELL, said sequence being essentially human. Homologous to a specific DNA sequence derived from TRELL, wherein the DNA encodes a polypeptide and the polypeptide is essentially homologous to a specific amino acid sequence derived from human TRELL. A DNA sequence that hybridizes to at least one fragment, wherein the fragment comprises at least 20 contiguous bases and the DNA sequence encodes a polypeptide that is at least 30% homologous to the active site of TRELL An array. [Selection figure] None |