Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_38951149229fc96b7d92410caba6e0ec |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-711 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 |
filingDate |
2009-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e640a53e4c5f778a2e03411f395ffeec |
publicationDate |
2009-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-2009173680-A |
titleOfInvention |
Recombinant antibody specific for β-amyloid terminus, DNA encoding the same, and method of use thereof |
abstract |
The present invention relates to a novel method for preventing the onset of Alzheimer's disease or suppressing the progression of Alzheimer's disease by stable expression in the brain of a recombinant antibody specific for the free terminal to amyloid-β peptide. Useful pharmaceutical compositions are provided. The present invention relates to a free end specific to the free N-terminus or free C-terminus of amyloid-β peptide operably linked to a promoter expressed in the central nervous system coupled to a gene delivery means. Containing a recombinant DNA molecule containing a gene encoding a recombinant antibody molecule and a pharmaceutically acceptable excipient, preventing accumulation of amyloid-beta peptide and aggregation of the peptide forming amyloid deposits in the brain The present invention relates to a pharmaceutical composition for preventing or suppressing the progression of Alzheimer's disease, which is useful for the prevention of amyloid-β peptide accumulation in the extracellular environment of neurons. [Selection figure] None |
priorityDate |
1997-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |