abstract |
[PROBLEMS] To develop and provide a drug that improves a disease or tissue condition accompanied by a decrease in the amount of collagen in the tissue. [MEANS FOR SOLVING PROBLEMS] Formula (I) (Wherein X represents a hydrogen atom, an alkyl group, etc., Y represents a hydrogen atom, an alkyl group, etc., and Z represents an alkylene having 1 or 2 carbon atoms which may be substituted with an alkyl group having 1 to 3 carbon atoms. Represents a chain, and R represents an alkyl group, an alkoxy group, or the like.) A composition for promoting and / or suppressing decrease in collagen accumulation, comprising a triazinoindoleamine compound represented by the formula (I) or a pharmaceutically acceptable salt thereof. 2. An effective amount of a triazinoindoleamine compound represented by formula (I) or a pharmaceutically acceptable salt thereof is applied to a non-human mammal that can be diagnosed with a disease or tissue condition accompanied by a decrease in the amount of collagen in the tissue. A method for promoting accumulation and / or suppressing decrease in the amount of collagen in a tissue, comprising a step of administering. [Selection figure] None |