| abstract |
PROBLEM TO BE SOLVED: To provide a novel coagulation factor VII polypeptide having an identical or increased activity compared to wild type factor VIIa and a factor VII derivative having an increased serum half-life. A region in the Factor VIIa molecule has been identified that allows changes to the primary structure as well as other modifications without affecting or reducing the biological activity of Factor VIIa. Novel human coagulation factor VII polypeptide, factor VII derivative utilizing the site, polynucleotide construct encoding such polypeptide, vector and polynucleotide comprising and expressing the host cell, polynucleotide Constructs, uses and treatment methods. [Selection figure] None |