| abstract |
Disclosed is a medicament useful for preventing and / or treating a disease associated with cell death such as cerebral infarction. A cell death-related protein kinase inhibitor comprising a substituted pyridine derivative represented by the general formula (1) and a pharmacologically acceptable salt thereof as an active ingredient. [In the formula, one of A and B is a nitrogen atom and the other is a carbon atom, D, E, and F represent a combination of O—C═N or N═C—S, and R has a substituent. A lower alkyl group which may have a substituent, an aromatic hydrocarbon lower alkyl group which may have a substituent, an aromatic hydrocarbon lower unsaturated alkyl group which may have a substituent, a mono or an optionally substituted substituent A di-lower alkylamino group or an amino group formed by ring formation of these di-lower alkyls is shown. ] [Selection figure] None |