| abstract |
To resolve 4- [4- (dimethylamino) -1- (4′-fluorophenyl) -1-hydroxybutyl] -3- (hydroxymethyl) -benzonitrile into its isolated enantiomers Providing a method for A racemic mixture or a non-racemic enantiomer mixture, 4- [4- (dimethylamino) -1- (4′-fluorophenyl) -1-hydroxybutyl] -3- (hydroxymethyl) -benzonitrile, is obtained. O, O'-di-p-toluoyl-tartaric acid as a salt with (+)-(S, S)-or (-)-(R, R) -enantiomer, solvent containing 1-propanol, ethanol or acetonitrile By fractional crystallization in the system, it can be resolved into enantiomers. [Selection figure] None |