| abstract |
A composition of naltrexone hydrochloride and a method for stabilizing the same are provided. For example, a pharmaceutical composition comprising an inert core, a first layer, a second layer and a third layer, wherein the first layer is between the core and the second layer; The second layer is between the first layer and the third layer, the first layer includes naltrexone hydrochloride and a stabilizer, the second layer includes a first hydrophobic material, and the second layer Naltrexone hydrochloride provided by inclusion of a second hydrophobic material and including one or more inert cores in the dosage form (ie, with the first, second, and third layers) A composition having a total amount of 20 mg or less. Stabilizers include, for example, organic acids, carboxylic acids, amino acid salts (for example, cysteine, L-cysteine, cysteine hydrochloride, glycine hydrochloride or cystine dihydrochloride), sodium metabisulfite, ascorbic acid and derivatives thereof, and the like. [Selection figure] None |