| abstract |
The present invention provides a method for evaluating the blood circulation promoting action of a test substance. In addition, a method (screening method) for searching for and obtaining a novel blood circulation promoting substance using the method is provided. Furthermore, the use of a substance whose blood circulation promoting action is evaluated by the evaluation method as a blood circulation promoter is provided. The method of evaluating blood circulation promoting action of a test substance using a method having the following steps: (1) The test substance is transdermally administered to a non-human animal, and the activity of the cutaneous artery sympathetic nerve of the non-human animal is evaluated. (2) When the activity of the cutaneous artery sympathetic nerve of the non-human animal administered with the test substance is lower than the activity of the cutaneous artery sympathetic nerve of the non-human animal not administered with the test substance And determining that the test substance has a blood circulation promoting action. In this way, linalool, geraniol, citral, citral dimethyl acetal, α-terpineol, terpinen-4-ol and urea were observed to have a blood circulation promoting action. [Selection figure] None |