| abstract |
Substituted 2- (2,6-dioxopiperidin-3-yl) -phthalimides and 1-oxo-2- (2,6-dioxopiperidine-3-) that can reduce the level of TNFα in mammals I) Provision of isoindolines. Specific embodiments include 1-oxo-2- (2,6-dioxo-3-methylpiperidin-3-yl) -4,5,6,7-tetrafluoroisoindoline, 1-oxo-2- (2,6-dioxo-3-methylpiperidin-3-yl) -4,5,6,7-tetrafluoroisoindoline, Oxo-2- (2,6-dioxopiperidin-3-yl) -4-aminoisoindoline, 2- (2,6-dioxo-3-methylpiperidin-3-yl) -4-aminophthalimide and the like. [Selection figure] None |