| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a7d918fd05361ab10fb2ab248a2e310 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J31-006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-575 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 |
| filingDate |
2009-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4aa4b5c29967b52ec9001dd7c40acd7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19bd00b8446163d0c6d7931c6e1967c5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e4112d8d9a8c11eb3eb8e76ac9053fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6e9b4f7e62ac5d3987784bcc2e9a257
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb80209bba880b60ddeb63673c8464c0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2214e3393d94309b7f48cff5b9ad0257
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0101a0e117c25aaa0cacb10f3a7aa79 |
| publicationDate |
2009-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2009138000-A |
| titleOfInvention |
Stereoselective synthesis of 24-hydroxylated compounds useful for the production of aminosterols, vitamin D analogs and other compounds |
| abstract |
The present invention provides a method for stereoselectively reducing an unsaturated alkyl ketone substituent bonded to a fused ring skeleton, and a method for producing squalamine or other useful aminosterol compounds. An unsaturated alkyl ketone is reacted with a chiral oxaazaborolidine reagent. This reaction stereoselectively reduces unsaturated alkyl ketones to unsaturated alkyl alcohols. If desired, the unsaturated alkyl alcohol can be further reduced to produce a saturated alkyl alcohol. The fused ring skeleton is, for example, a steroid ring skeleton or a skeleton of a vitamin D analog, and an alkene on the steroid ring skeleton to produce squalamine or other useful aminosterol compounds and intermediates for the production of aminosterol compounds. It can be used with an on substituent (eg, 22-en-24-one substituent) or an alkyne on substituent (eg, 22-in-24-one substituent). [Selection figure] None |
| priorityDate |
1996-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |