http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009114121-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ddb9f3656270bc5410be3679322fead |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 |
| filingDate | 2007-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01e81b2c5f3d50ba50fe5a28ae87d69c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_202181ed9c332cf101f14b521f2f0a0f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da944f798c5fa1fd2edc1d79e5ae31ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2434fb566f776eea2d60aae4bfae5d91 |
| publicationDate | 2009-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2009114121-A |
| titleOfInvention | Method for producing simvastatin |
| abstract | PROBLEM TO BE SOLVED: To produce high-purity simvastatin in a high yield by a convenient and industrially advantageous method. In an aprotic polar solvent and a hydrocarbon solvent, in the presence of water, general formula (3); Embedded image Simvastatin is produced by allowing an acid to act on the compound represented by: Preferably, triol acid is converted into acetonide, the obtained acetonide form is acylated, and further acyl form of deacetonide and simvastatin obtained by lactonization are mixed with an aromatic hydrocarbon solvent and an aliphatic hydrocarbon solvent. Simvastatin is produced by subjecting it to crystallization and / or crystallization using a mixed solvent of a ketone solvent or a nitrogen-containing solvent and water. [Selection figure] None |
| priorityDate | 2007-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 123.