| abstract |
Disclosed are compounds that inhibit caspases that cause cell apoptosis and inflammation, and pharmaceutical compositions thereof. A compound of formula (I) wherein R 1 , R 2 , R 3 , R 4 , and R 5 represent specific substituents. In addition, pharmaceutical compositions and methods of using such compositions to treat caspase-mediated diseases, as well as processes for preparing these compounds are also provided. It is in the field of medicinal chemistry and relates to compounds and their pharmaceutical compositions that inhibit caspases leading to cellular apoptosis and inflammation. [Selection figure] None |