| abstract |
Compounds useful in the treatment of angiogenic diseases in mammals, particularly safe for therapeutic use and exhibiting little or no toxicity to, for example, normal (ie, non-cancerous) cells The present invention provides a compound serving as an anti-angiogenesis inhibitor, which exhibits selective toxicity against pathological symptoms by selectively inhibiting the proliferation of endothelial cells. Structural formula A-B-C-X-Y wherein A is absent or a nitrogen protecting group, Y is absent or a carboxylic acid protecting group, and B is a natural amino acid residue. , C is R 1 —R 2 —R 3 —R 4 [Lysyl, Leucyl or Arginyl, Tyrosyl, etc., Aspartyl], X is Absent or Natural Amino Acid Residue, etc.] Fragment of Mammalian Kringle (5) And Kringle (5) a method and compound for inhibiting angiogenic diseases, wherein the fusion protein is a compound for treating angiogenic diseases. [Selection figure] None |