| abstract |
Provided are methods and compositions for the treatment of neuronal disorders that disrupt hypersynchronous neuronal activity without compromising neuronal excitability and spontaneous synchronization required for normal functioning of the peripheral and central nervous systems. . A Na + -K + -2Cl - (NKCC ) reducing the effective amount of the co-transporter, inactivating, and / or administering the agent that is effective in inhibiting the activity Relates to methods and compositions for treating neuropathic pain and neuropsychiatric disorders. In certain embodiments, Na + -K + -2Cl - cotransporter is NKCC1. The compositions and methods of the present invention do not suppress neuronal excitability, thus avoiding the undesirable side effects often associated with drugs currently used for the treatment of neuropathic pain and neuropsychiatric disorders. It can be used to reduce neuronal hypersynchronization and / or neuropsychiatric disorders associated with impaired pain. [Selection figure] None |