| abstract |
Disclosed is a drug for controlling pain. Peptide sequences derived from the V5 domain of protein kinase C isozymes for use in pain management (eg, peptides derived from the V5 domain of γ-protein kinase C (γPKC) or ε protein kinase C (εPCK)) Wherein the peptide has isozyme-specific activity for the modulation of pain. Also described are compositions comprising peptides for treating pain and / or inducing analgesia. Methods of treating pain and identifying compounds that mimic the activity of this peptide are also described. [Selection figure] None |