| abstract |
The present invention provides an amide derivative having an excellent S1P 1 receptor selective agonistic action. SOLUTION: General formula (1) [In the formula, R 1 represents a benzyloxy group, an alkyl group having 1 to 6 carbon atoms which may be substituted with a halogen atom, R 2 represents — (O) p- (CR a R b ) q-COOH or - a (CR c R d) q- PO 3 H 2, R 3 is a hydrogen atom, a halogen atom, a nitro group, a X is a hydrogen atom or a halogen atom, Y is O, S, SO or SO 2, Z represents —CONH— or —NHCO—, and T represents —CH═CH— or — (CH 2 ) m—. Or a pharmaceutically acceptable salt or hydrate thereof. [Selection figure] None |