| abstract |
Therapeutic peptides are modified to protect them from peptidase activity and provide a longer duration of action in vivo while maintaining low toxicity, yet the therapeutic benefits of modified peptides Provide a way to hold. A modified therapeutic peptide, wherein the therapeutic peptide can form a peptidase-stabilized therapeutic peptide conjugate, the peptide being carboxy-terminal amino acid, amino-terminal amino acid, by structure-activity relationship analysis Includes identified therapeutically active regions and lower therapeutically active regions. The peptide includes peptide YY, or a derivative thereof, which has a reactive group attached to an amino acid that is located in the lower therapeutically active region of the amino acid. [Selection figure] None |