| abstract |
A method of treating or diagnosing a cancer associated with P-cadherin expression targets P-cadherin, wherein the cancer is characterized by overexpression and / or upregulation of P-cadherin. Provided using a ligand, specifically a human anti-P-cadherin antibody. Also provided is a screen for identifying anti-P-cadherin antibodies having therapeutic activity. P-cadherin is a transmembrane protein that is part of a class of proteins that are linked to the cytoskeleton of a cell through the formation of a complex by the binding of a complete transmembrane protein with a cytosolic protein (catenin). [Selection figure] None |