| abstract |
To provide a modified nucleic acid synthesis method using an amidite for modified nucleic acid synthesis. A protective group that can be deprotected in an aprotic solvent, and when the protective group is deprotected, a hydroxyl group is expressed in the substituent. And a modified nucleic acid synthesis method using the amidite for synthesis of modified nucleic acid. In the general formula (I), X represents a base, Y represents a substituent, Z represents a protecting group for protecting a hydroxyl group in the substituent, and Q represents a hydrogen atom, a hydroxyl group, or a protecting group. Represents a hydroxyl group protected with. [Selection figure] None |