http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009057358-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d85adfc4b306a4a626f7f235ffc6674 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-352 |
| filingDate | 2007-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a449937c983a4a96668f4c68ad1e8c61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_376832790256be5ee87e3ea7c5ae257a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d443db0ffa067fc13b234a69fd9cf34e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87f20f6a2c7917d3229197434e1d99b2 |
| publicationDate | 2009-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2009057358-A |
| titleOfInvention | Gene expression inhibitor and suppression technology |
| abstract | Disclosed are an MMP-7 gene expression inhibitor and a suppression technique that are effective in suppressing invasion and metastasis of liver cancer cells. The effect on the proliferation of cultured human hepatoma cells is evaluated in an MTT assay, and the ability of cancer metastasis is evaluated in an in vitro invasion assay. Furthermore, the amount of transcription of the MMP-7 gene, whose gene expression is known to be involved in cancer cell metastasis, is evaluated by RT-PCR, and further, the binding site is present in the promoter region of the MMP-7 gene. By evaluating the inhibitory effect of TPA on the binding activity of the transcription factor NF-κB in a gel shift assay, isoflavidine (7-Hydroxy-6,8-dimethylcoumarin) is provided as a substance having an inhibitory action. [Selection] Figure 3 |
| priorityDate | 2007-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 245.