abstract |
An object of the present invention is to provide a caspase inhibitor. The present invention is a compound as described herein, wherein R 1 is CO 2 H, CH 2 CO 2 H, or an ester, amide, or isostere thereof; R 2 and R 3 is independently selected from hydrogen or optionally substituted C 1 -C 6 aliphatic groups; and R 4 and R 5 are each independently hydrogen, optionally substituted C 1 -C 6 aliphatic groups are selected, or R 4 and R 5 together with the ring to which they are attached form what is optionally substituted to form a bicyclic ring To do. This caspase inhibitor is useful for the treatment of many diseases such as cancer, acute inflammation and autoimmune disorders, ischemic diseases, and certain neurodegenerative disorders. [Selection figure] None |