| abstract |
A cross-linked polymer composition is bonded to a second synthetic polymer having a plurality of electrophilic groups by a covalent bond to achieve adhesion between native surfaces and achieve tissue enhancement. A first synthetic polymer comprising a nucleophilic group of The first synthetic polymer is preferably a synthetic polypeptide or polyethylene glycol modified to contain a plurality of nucleophilic groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain two or more electrophilic groups. The composition may further comprise other ingredients. Also, a method of achieving adhesion between a first surface and a second surface by using a crosslinked polymer composition, a method of achieving tissue augmentation, a method of preventing the formation of surgical adhesions, and synthesis A method for coating the surface of an implant is also disclosed. [Selection figure] None |