http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009027982-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_716e9a2606ffd4ba1a2a3917e4a402fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_129e393582e6bdf4029baf2206522f45 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2007-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_880709d05e3a32e83a01d2da31e0405e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdcf920baf92cff0919ce9e22614238d |
| publicationDate | 2009-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2009027982-A |
| titleOfInvention | Prediction of drug interaction and blood immunosuppressant concentration fluctuations in organ transplant patients coadministered with immunosuppressants and proton pump inhibitors |
| abstract | [PROBLEMS] To predict drug interaction between an immunosuppressant and a proton pump inhibitor (PPI) and a change in blood immunosuppressant concentration in an organ transplant patient. The genetic polymorphisms of human cytochromes P450 3A5 and 2C19 in biological samples of both organ transplant patients and organ donors are measured, thereby (1) the human cytochromes of organ transplant patients and organ donors. When both of the gene polymorphisms of P450 3A5 and 2C19 are mutated, it indicates that the blood immunosuppressant concentration exceeds the maximum allowable level in the patient and causes side effects, and the side effects are suppressed or avoided. If the type of PPI is selected and / or (2) at least one of the human cytochrome P450 3A5 and 2C19 gene polymorphisms of an organ transplant patient or organ donor is wild type, blood immunity in the patient Indicates that the inhibitor concentration is below the maximum acceptable level and does not cause side effects, and any kind of P I is selected, the method comprising. [Selection] Figure 1 |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114209844-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114350788-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114350788-B |
| priorityDate | 2007-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1108.