| abstract |
An object of the present invention is to provide a stable calcium statin salt that is easily reproducible and that uses a process that can withstand large-scale production and that uses a small number of steps. A method is provided for producing a calcium salt of a statin from the ester derivative or protected ester derivative of the statin by using calcium hydroxide. The ester or protected ester derivative is contacted with calcium hydroxide to obtain a calcium salt. Preferred statins are rosuvastatin, pitavastatin and atorvastatin, simvastatin and lovastatin. In methods starting with protected statin ester derivatives, the protecting group is hydrolyzed during salt formation by contact with calcium hydroxide or contacted with calcium hydroxide after contact with an acid catalyst. [Selection figure] None |