| abstract |
A polymer composition for use in delivering a macrocyclic triene compound to a subject is described. The polymer composition comprises a polymer substrate comprising a 40-O-hydroxyalkyl rapamycin derivative of a macrocyclic triene compound, the alkyl group comprising 7 to 11 carbon atoms. This composition is useful for treating any condition that responds to rapamycin or everolimus, and a method of treatment using the polymer composition is described. The composition is for use in the treatment of solid tumors, inflammation or wounds at the target site and is composed of a suspension of injectable particles that can be localized by injection into the target site. [Selection figure] None |