| abstract |
The present invention relates to a series of inflammations that increase EETs by inhibiting sEH activity, reduce blood pressure based on vasodilatory action, renal diseases, cardiovascular diseases including cerebral infarction, and activation of NFκB / IκB kinase. Provided are 2-aryl-benzimidazole derivatives which are expected as therapeutic agents for sex diseases or autoimmune diseases, as well as therapeutic agents for endocrine metabolic diseases including hyperlipidemia and diabetes and adult respiratory distress syndrome. The compound of the present invention is a 2-aryl-benzimidazole derivative represented by the following formula or a pharmaceutically acceptable salt or hydrate thereof. |