| abstract |
Compositions and methods are provided for the diagnosis and treatment of tumor cell growth and proliferation in mammals, including humans. A method for identifying a gene amplified in the genome of a tumor cell. Such gene amplification is expected to contribute to tumorigenesis associated with overexpression of the gene product compared to normal cells of the same tissue type. Therefore, the protein encoded by the amplified gene is considered useful for the diagnosis and / or treatment (including prevention) of certain cancers and acts to predict the prognosis of tumor treatment. A novel polypeptide and a nucleic acid molecule encoding the polypeptide. A vector and host cell containing the nucleic acid sequence, a chimeric polypeptide molecule comprising the polypeptide of the present invention fused to a heterologous polypeptide sequence, an antibody that binds to the polypeptide of the present invention, and a method for producing the polypeptide. [Selection figure] None |