abstract |
The present invention relates to therapeutic use to increase androgen levels, androgen replacement, testosterone replacement, and use as a drug for benign prostatic hyperplasia (BPH), and male contraception, preferably progestagen infertility. Formula (1) for use as the only means of achieving both drug efficacy and androgen supplementation Wherein R 1 is O, (H, H), (H, OH), or NOR (R is hydrogen, (C 1-6 ) alkyl or (C 1-6 ) acyl). R 2 is hydrogen, methyl, ethyl or ethenyl, R 3 is hydrogen, methyl, ethyl, ethenyl, fluorine or chlorine, R 4 is methyl or ethyl, R 5 is hydrogen, Methyl or ethyl, R 6 is hydrogen, methyl, ethyl, (C 1-3 ) alkenyl or (C 1-3 alkynyl), R 7 is hydrogen or (C 1-15 ) acyl, And at least one of R 5 or R 6 is hydrogen. Or a pharmaceutically acceptable salt thereof. |