| abstract |
The present invention relates to small molecule protein tyrosine phosphatase inhibitors, in particular Shp-2 inhibitors of formula (I) and / or (II), and pharmaceutical compositions comprising them. The present invention is also directed to the use of said compounds for the treatment of phosphatase mediated diseases, especially cancer and metastasis. The present invention further provides a method for such treatment in a patient in need of treatment of proliferative disease, genetic disease, autoimmune disease, angiogenesis disorder or cancer, wherein said patient comprises formula (I) And / or a method comprising administering a therapeutically effective amount of at least one compound of (II). |