abstract |
The present invention relates to a general formula (I) for the manufacture of a therapeutic agent for inflammatory diseases: [Where z is 1, 2, 3 or 4; A is —CO— or —SO 2 —; Q is linear or branched alkyl, alkenyl, alkynyl, alkoxy, oxyalkyl, aminoalkyl, alkylamino, alkylaminoalkyl, haloalkyl, aryl or substituted aryl; T 1 and T 2 together form a cycloalkyl, cycloalkenyl or polycycloalkyl radical consisting of n additional carbon atoms, where n is 2-7; Each hydrogen atom bonded to a carbon atom in the ring produced by T 1 and T 2 may be independently substituted by the group R 1 , where R 1 is independently 1-20 carbon atoms. Selected from alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radicals; or each R 1 is independently fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl Selected from radicals. ] (Except for (S) -3- (1′-methylcyclohexylcarbonylamino) -caprolactam), pharmaceutical compositions, and uses of the compounds and salts thereof. |