| abstract |
The present invention relates to a method of modulating poly (ADP-ribose) polymerase-1 (PARP-I) in an animal, wherein the mammal is provided with an effective amount of an aromatic organic compound having 4 to about 35 carbon atoms. Wherein the aromatic organic compound has an electron donating ability so that the π-electron system is positively charged at a specific arginine-34 residue of zinc 1 finger of PARP-I. Interacts with the formed (cationic) guanidinium moiety. In particular, pharmaceutical compositions comprising substituted benzopyrones and substituted indoles and such compounds that modulate the activity of PARP-1 are described. The present invention is a pharmaceutical composition, kit, and method for treatment and / or prevention in the treatment of the diseases and disorders described herein, by administering an effective amount of such a compound. Regarding the method. Preferably, the compositions and methods provided herein inhibit PARP activity. |