abstract |
General formula (I) or (I ′) wherein R 1 , R 2 , R 3 and R 4 are the same or different and represent amino acid side chain moieties, and each R 6 is the same Compounds that are FK228 analogs of hydrogen or C 1 -C 4 alkyl (differently representing), their isosteres and their pharmaceutically acceptable salts are found to inhibit HDAC. Embedded image |