http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008541764-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-002 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0058 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0066 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
| filingDate | 2006-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2008541764-A |
| titleOfInvention | Glucose-induced insulin expression and methods for treating diabetes |
| abstract | The present invention relates to a 3 ′ of at least one tripartite transcription factor binding cis element having a hepatocyte nuclear factor-1 (HNF-1) element, a CAAT / enhancer binding protein (C / EBP) response element and a glucose response element (GRE). Provided is an isolated tissue specific glucose responsive promoter having a polymerase binding domain on its side. The promoter can include a second or third tripartite transcription factor binding cis element. Host cells comprising the tissue specific glucose responsive promoters of the present invention are also provided. Further provided are methods for treating or preventing diabetes. This method comprises a hepatocyte nuclear factor-1 (HNF-1) element, a CAAT / enhancer binding protein (C / EBP) response element and a glucose response element (GRE) operably linked to a nucleic acid encoding insulin. Administering to the individual an effective amount of a viral particle having a vector comprising a tissue-specific glucose responsive promoter comprising a polymerase binding domain 3 'to at least one tripartite transcription factor binding cis element comprising insulin Expression of the encoding nucleic acid is tissue specific and glucose responsive. [Selection] Figure 1 |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018509141-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016537987-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019520837-A |
| priorityDate | 2005-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 639.