| abstract |
The compound of formula (IA) or (IB) is an inhibitor of Aurora kinase activity: In formula (IA), (IB), -L1Y1- [CH2] z- is a linker group, where Y 1 , L 1 and z are as defined in the claims; R 6 is C 1 -C 4 alkoxy, hydrogen or halo; W is a bond, —CH 2 —, —O—, —S -, -S (= O) 2- , or -NR 5- (where R 5 is hydrogen or C 1 -C 4 alkyl); Q is = N-, = CH- or = C (X 1 ) — (where X 1 is cyano, cyclopropyl or halo); the linker group L 2 is as defined in the claims; R is of formula (X) or A group of (Y), wherein R 1 is a carboxylic acid group (—COOH) or an ester group hydrolyzable to a carboxylic acid group by one or more intracellular carboxylesterase enzymes; R 4 It is hydrogen or optionally substituted in the C 1 -C 6 alkyl, C 3 -C 7 Shi Roarukiru, aryl, aryl (C 1 -C 6 alkyl) -, heteroaryl, heteroaryl (C 1 -C 6 alkyl) -, - (C = O ) R 3, - (C = O) OR 3, or - (C = O) NR 3 (wherein R 3 is hydrogen or optionally substituted (C 1 -C 6 ) alkyl, C 3 -C 7 cycloalkyl, aryl, aryl (C 1 -C 6 alkyl)-, heteroaryl, or heteroaryl (C 1 -C 6 alkyl)-; R 4 1 is hydrogen or optionally substituted C 1 -C 6 alkyl D is a monocyclic heterocyclic ring of 5 or 6 ring atoms. [Selection figure] None |