| abstract |
The present invention relates to novel isolated and purified polynucleotides and polypeptides relating to the functional motif of Nogo receptor (NgR1), and NgR1 ligands (eg, myelin-binding glycoprotein, oligodendrocyte myelin glycoprotein, Nogo-A). , Nogo-66, antibodies to Nogo receptor, antibodies to GT1b, antibodies to p75 neurotrophin receptor and antibodies to Lingo-1). The invention also provides antibodies against mimetic peptide antagonists. The present invention tests for new therapies and therapeutic targets, as well as treatments that require axon regeneration (ie, reverse the effects of NgR1 ligand binding to NgR1 (ie, resulting in inhibition of axon growth)). It further relates to methods for screening and evaluating compounds. |