http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008539197-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2006-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2008539197-A |
| titleOfInvention | Benzotriazole derivatives as cannabinoid receptor antagonists |
| abstract | The present invention is useful in the treatment of obesity, psychiatric and neurological disorders, and other diseases including cannabinoid-CB 1 neurotransmission (Current Opinion in Drug Discovery & Development 2004 7 (4): 498-506). The following class of benzotriazole derivatives, pharmaceutically acceptable acid addition salts and stereoisomers thereof, which are potent cannabinoid-CB 1 modulators (known as antagonists or inverse agonists), wherein R 1 is hydrogen, Halo, trifluoromethyl, C 1-4 alkyl, C 1-4 alkyloxy- or C 1-4 alkyloxycarbonyl; R 2 is hydrogen, phenyl, C 3-7 cycloalkyl or optionally substituted with Ar 1 C 1-6 alkyl which may be have been By and; R 3 is hydrogen, hydroxyl or C 1-6 alkyl; Ar 1 is phenyl which is substituted by three halo substituents phenyl or up; and Het is furanyl, thienyl, pyrrolyl, oxazolyl, Monocyclic 5- or 6-membered partially saturated or aromatic complex selected from thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl, pyrimidinyl, pyridinyl, pyrazinyl, triazinyl, pyridazinyl, 2H-pyranyl or 4H-pyranyl Represents a ring, wherein the heterocycle may be optionally substituted with C 1-6 alkyl. |
| priorityDate | 2005-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 116.